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Weed is not physically harmful, however anything that alters you mind-state has the potential to be. Meaning, driving/operating machines or things like that while impaired is extremely dangerous. Also, people can get addicted to the high.
Prolonged marijuana use also alters brain structure and function, especially at younger ages. A study found that teenagers who used marijuana for 3 years daily had changes in brain structure related to working memory and performed more poorly on memory-related tasks and the decline remained a few years after use ended. The study also asserted a connection between young people using marijuana and the changes in the brain leading to the development of schizophrenia (I believe the evidence of this, given the circumstances of the study, is minimal).